Swiss scientists have developed an experimental skin implant that darkens like a mole when it detects subtle changes in the body that may be an early warning sign of cancer, a study said Wednesday.

The implant, or "biomedical tattoo," as researchers call it, has been tested in lab animals, lasts about a year and recognizes the four most common types of cancer: prostate, lung, colon and breast cancer.

It works by reacting to the level of calcium in the blood, which rises when a tumor is developing. About 40 percent of cancers could theoretically be detected this way, researchers said.

"The biomedical tattoo detects all hypercalcemic cancers at a very early, asymptomatic stage," lead author Martin Fussenegger, Professor at the Department of Biosystems Science and Engineering at ETH Zurich, told AFP by email.

"If blood calcium levels remain high over longer periods of time, the calcium sensor in the biomedical tattoo cells produces an enzyme, tyrosinase, which converts the amino acid into the black skin pigment, melanin."

If the wearer notices the spot darken, they should see a doctor to clarify the reason for the change and determine if or what treatment is warranted, he said.

"Early detection increases the chance of survival significantly," he said.

"Nowadays, people generally go to the doctor only when the tumor begins to cause problems. Unfortunately, by that point it is often too late."

The implant was tested in mice with either cancerous tumors that cause hypercalcemia or tumors that do not affect calcium blood levels.

During a 38-day experiment, the tattoos appeared only on the skin of the hypercalcemic mice, which showed no symptoms of illness.

More research and funding is needed to advance the tattoo to clinical trials in people, and the process could take a decade, Fussenegger said.

A paper describing the prototype was published in the journal Science Translational Medicine.

Related Links
Space Technology News - Applications and Research

Tweet

Thanks for being here; We need your help. The SpaceDaily news network continues to grow but revenues have never been harder to maintain. With the rise of Ad Blockers, and Facebook - our traditional revenue sources via quality network advertising continues to decline. And unlike so many other news sites, we don't have a paywall - with those annoying usernames and passwords. Our news coverage takes time and effort to publish 365 days a year. If you find our news sites informative and useful then please consider becoming a regular supporter or for now make a one off contribution.
SpaceDaily Contributor $5 Billed Once credit card or paypal		SpaceDaily Monthly Supporter $5 Billed Monthly paypal only

Plants fix UV damage to DNA with robust repair system
Washington (UPI) Apr 17, 2018
Scientists have detailed the ability of plants to repair DNA damaged by the sun's ultraviolet rays. The new study, published this week in the journal Nature Communications, marks the first time scientists have mapped the "nucleotide excision repair" system inside an entire multicellular organism. The newly mapped system is similar to DNA repair systems found in humans and other animals but is more efficient at repairing active genes. "These findings advance our understanding of DN ... read more