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Insulin-Signaling Possible Key To Extended Longevity
UPI Correspondent Boston (UPI) July 20, 2007 New research shows it may be possible to one day take a life-extending pill that mimics the healthy effects of exercise and a low-calorie diet by lowering insulin signaling in the brain. The key to a longer life is lower insulin levels, said Morris White, a pediatrician and endocrinologist at Howard Hughes Medical Institute. Less insulin helps cells fend off diseases that lead to an early death, like cancer, said White, whose study appears in Thursday's Science. "With calorie restriction and exercise, cancer, diabetes, cardiac disease and others all get postponed. It still happens, but at a later age. It's thought to be at least partly involved in the longer life span," White told United Press International. Insulin is the substance made by the pancreas that allows cells to metabolize glucose, and that diabetics need. But recent research shows that too much insulin is far from helpful, and instead makes cells vulnerable to diseases that may shorten life, like cancer, artery disease, Alzheimer's and Parkinson's disease. While lowering insulin throughout the body can lead to a diabetic state, scientists found that allowing insulin levels to be high throughout most of the body, and lowering the insulin signaling only in the brain through genetic manipulation, extended the life of mice. In White's study, the scientists manipulated genes in mice to produce 50 percent less insulin and saw the mice live 18 percent longer. The same effect happens through exercise and eating 60 percent fewer calories than normal, he said. Although the mice were overweight, they lived longer and seemed active and youthful, White noted. This result in particular seems to open the door to the possibility that people can one day take a pill that will offer extra protection against life-shortening diseases, White said. "Maybe if we can decrease insulin signaling in the brain, then this will be a very broad approach to reducing cancer and other diseases, despite putting on weight. So you wouldn't have to go for a 60-percent calorie restriction," White said. "And you'd feel your life is longer because you wouldn't be miserable from dieting," White added. Some people who live past 100 may have a natural genetic tendency for lower insulin signaling in the brain. They eat a normal amount of calories or are even be a bit overweight, but still enjoy the benefit of life extension, White said. Research on diet, exercise, insulin and life extension has sped up worldwide, and today many laboratories are doing this research, said Makoto Kuro-o, assistant professor of pathology at University of Texas Southwestern Medical Center. Kuro-o discovered a protein in mice, dubbed Klotho, that controls insulin and extends life. Klotho appears to be a different mechanism from the genetic manipulation under way in White's laboratory. "In the past several years there have been a lot of studies of insulin in flies and worms. These studies probably gave us a very good clue to applying the findings directly to mammals," Kuro-o told UPI. "We actually don't know about brain function and what insulin is doing in the brain. I think at least we are at the entry gate," Kuro-o said.
Source: United Press International Related Links Hospital and Medical News at InternDaily.com
Scientists Invent Novel Hydrogels For Repairing And Regenerating Human Tissue
Newark, DE (SPX) Jul 20, 2007University of Delaware scientists have invented a novel biomaterial with surprising antibacterial properties that can be injected as a low-viscosity gel into a wound where it rigidifies nearly on contact--opening the door to the possibility of delivering a targeted payload of cells and antibiotics to repair the damaged tissue. Regenerating healthy tissue in a cancer-ridden liver, healing a biopsy site and providing wounded soldiers in battle with pain-killing, infection-fighting medical treatment are among the myriad uses the scientists foresee for the new technology. |
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