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EPIDEMICS
Small US trial looks at body's ability to fight HIV
by Staff Writers
Washington (AFP) March 7, 2012


A new approach to coaxing the body to fight HIV without antiretroviral drugs has shown some success in almost half the patients enrolled in a small study, US researchers said Wednesday.

Twenty HIV-positive volunteers in Pennsylvania were asked to stop taking their drug therapy and submit instead to weekly doses of interferon-alpha, an antiviral chemical produced by the human immune system.

The treatment kept HIV under control in nine of the 20 patients at the 12-week mark, and appeared to decrease the amount of HIV present in cells that harbor the infection, known as reservoirs.

The trial was meant to last 24 weeks or until a person's HIV levels either rose or T-cells dropped to a certain level, at which point the subjects were to resume their antiretroviral treatment.

Just eight people stayed in the study for its full 24-week duration.

However, researcher Luis Montaner, a professor at the Wistar Institute and director of its HIV-1 Immunopathogenesis Laboratory, was optimistic that the findings had broken new ground.

"Our data shows that our human immune response can be made to control HIV in persons who have otherwise lost that ability and, if sustained by natural interferon production, it establishes proof-of-concept that a functional cure is theoretically possible," Montaner said in a statement.

"And while we still have much to pursue with this early clinical finding, I firmly believe this gives us hope that one day we can control -- and eventually eradicate -- HIV in absence of antiretroviral therapy."

The research, which has not been published or independently peer-reviewed, was presented at the 2012 Conference on Retroviruses and Opportunistic Infections in Seattle, Washington.

Relief agencies help victims of Madagascar storm
Antananarivo (AFP) March 6, 2012 - Relief agencies and government officials started distributing emergency supplies Tuesday to Madagascan communities impacted by Tropical Storm Irina, which killed at least 65 people.

Prime Minister Jean Omer Berizky's office said the government had delivered 15 tonnes of white rice and several tonnes of beans to affected districts.

The United Nations World Food Programme and UNICEF said they had sufficient food to help people for several days.

Irina was the second killer storm of the season. Last month, tropical cyclone Giovanna left 35 people dead and many more injured.

Madagascar's storm season normally runs from November through February and costs dozens of lives every year.

Related Links
Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola




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Bird flu claims fifth victim this year in Indonesia
Jakarta (AFP) March 7, 2012 - A 24-year-old woman has died of bird flu on Indonesia's Sumatra island, the fifth human death from the virus this year, a health ministry official said Wednesday.

"She tested positive for the H5N1 virus by the health ministry's laboratory. It's the fifth death here this year," the ministry's head of animal-borne infectious diseases, Rita Kusriastuti, told AFP.

Concerns about avian influenza have risen in Asia since China in late December reported its first fatality from the H5N1 virus in 18 months. Since then one more person has died in China, according to the health ministry.

Indonesia has been the nation hardest-hit by bird flu, with 150 deaths reported between 2003 and 2011, according to the World Health Organization. Nine Indonesians died from the virus last year.

"The woman was living in an area where there are many ducks and chickens. She also had some (poultry) in her house," Kusriastuti said, adding that she died on March 1 in a hospital in Bengkulu city.

The virus typically spreads from birds to humans through direct contact, but experts fear it could mutate into a form that is easily transmissible between humans, with the potential to kill millions in a pandemic.



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EPIDEMICS
Cuba to test new AIDS vaccine on humans
Havana (AFP) March 5, 2012
Cuba's top biotech teams have successfully tested a new AIDS vaccine on mice, and are ready to soon begin human testing, a leading researcher told a biotechnology conference in Havana on Monday. "The new AIDS trial vaccine already was tested successfully (on mice) and now we are preparing a very small, tightly controlled phase one clinical trial" with HIV-positive patients who are not in the ... read more


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