Beijing is a crucial ally for cash-strapped Pakistan but Chinese-funded infrastructure projects have sparked resentment and its nationals are routinely targeted by militant groups.
Tuesday's incident took place near an industrial district of the southern port city of Karachi, a provincial minister told AFP.
"Both are under treatment, but I cannot comment on their condition," a senior health official at the Liaquat National Hospital told AFP, asking not to be identified.
Beijing demanded tighter security last month after a massive blast targeting a convoy of Chinese workers in Karachi killed two of its nationals.
Weeks after the attack, media reported that the Chinese ambassador to Pakistan Jiang Zaidong labelled the violence "unacceptable".
Police did not give any details about Tuesday's incident but provincial home minister Zia Ul Hassan Lanjar asked authorities "to arrest the security guard involved" in protecting the Chinese nationals, according to a statement by his office.
He also ordered "an audit of all companies providing security to Chinese nationals and foreigners".
China has poured tens of billions of dollars into Pakistan to fund massive transport, energy and infrastructure projects -- part of Beijing's transnational "Belt and Road" scheme.
Several of the projects are housed in southwestern Balochistan province, where Pakistan's military has been fighting a decades-long insurgency, sparking a series of targeted attacks primarily carried out by the separatist Baloch Liberation Army (BLA).
More than twenty Chinese nationals have been killed in Pakistan in the past three years.
In June 2020, Baloch insurgents targeted the Pakistan Stock Exchange, which is partly owned by Chinese companies, in commercial capital Karachi.
In 2019, gunmen stormed a luxury hotel in Balochistan province overlooking the flagship Chinese-backed deepwater seaport in Gwadar that gives strategic access to the Arabian Sea -- killing at least eight people.
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