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EPIDEMICS
UK team tests China virus vaccine on mice
By William EDWARDS
London (AFP) Feb 11, 2020

World scientists meet to fight novel coronavirus
Geneva (AFP) Feb 11, 2020 - Scientists from around the world are reviewing how the novel coronavirus is transmitted and possible vaccines at a World Health Organization conference that kicked off on Tuesday.

"What matters most is stopping the outbreak and saving lives. With your support, that's what we can do together," WHO chief Tedros Adhanom Ghebreyesus said at the two-day Geneva gathering.

WHO said some 400 scientists were taking part.

The virus, first identified in China on December 31, has killed more than 1,000 people, infected over 42,000 and reached some 25 countries.

Participants will also discuss the source of the virus, which is thought to have originated in bats and reached humans via another animal such as snakes or pangolins.

There is no specific treatment or vaccine against the virus, which can cause respiratory failure.

Tedros, who has repeatedly urged countries affected to share their data, called for global "solidarity".

"That is especially true in relation to sharing of samples and sequences. To defeat this outbreak, we need open and equitable sharing, according to the principles of fairness and equity," he said.

"We hope that one of the outcomes of this meeting will be an agreed roadmap for research around which researchers and donors will align," Tedros said.

Several companies and institutes in Australia, China, France, Germany and the United States are racing to develop a vaccine -- a process that normally takes years.

Asked whether scientists from Taiwan would be allowed to take part in this week's Geneva conference, WHO officials said that they would do so but only online -- along with colleagues from other parts of China.

While the WHO does not deal with Taiwan directly and only recognises Beijing, Taiwan was often allowed to attend annual assemblies and sideline meetings as an observer.

But in recent years it has been frozen out as Beijing takes an increasingly combative stance towards democratic Taiwan, which it considers its own territory.

A team of UK scientists believe they are among the first to start animal testing of a vaccine for the new coronavirus outbreak that has killed more than 1,000 people and spread around the world.

Researchers at Imperial College London said their ultimate goal was to have an effective and safe way of halting the SARS-like strain's spread by the end of the year.

"At the moment we have just put the vaccine that we've generated from these bacteria into mice," Imperial College London researcher Paul McKay told AFP in an interview on Monday.

"We're hoping that over the next few weeks we'll be able to determine the response that we can see in those mice, in their blood, their antibody response to the coronavirus."

Scientists across the world are racing to develop a way to stamp out the new strain of a well-known virus that has been successfully combatted in the past.

Imperial College London said it cannot be sure how advanced other teams' research is at the moment.

China's Xinhua state news agency cited a local news report as saying that a Shanghai university also injected a test vaccine into mice on Sunday.

But the local report cited unnamed sources and there has been no official announcement about the Chinese tests.

Britain has recorded eight cases of the virus and been forced to shut down two branches of a medical centre in the southeast city of Brighton where at least two staff members tested positive.

But coming up with a vaccine is a laborious process that usually involves years of animal testing and clinal trials on humans.

Regulators must then make sure that the vaccine is both sufficiently safe and effective to be mass produced.

Imperial College London hopes that research on the SARS coronavirus nearly two decades ago can speed things up.

"We're hoping to be the first to get this particular vaccine into human clinical trials, and that perhaps is our personal goal," McKay said.

"Once the phase one trial is complete -- which can take a few months to complete -- it can be immediately started into an efficacy trial in people, which will also take a few months to complete," McKay added.

"So, perhaps by the end of this year there will be a viable tested vaccine that would be suitable for use in people."

- 'Collaborative race' -

Much of the world's current research into the new strain is being funded through the Coalition for Epidemic Preparedness Innovations (CEPI).

The group was formed at the 2017 World Economic Forum in Davos to help drug companies and universities join forces and stamp out dangerous and preventable diseases.

Imperial College London is not working with any of the current teams partnering with CEPI and requires its own sources of funding.

Its scientists hope that successful animal testing can help secure investments that allow clinical trials to start some time between June and August.

McKay said it would be unfair to say that the various universities and companies are competing to become the first to develop a vaccine.

"There's been so much cross-sharing with all of this information -- I mean the Chinese, as soon as the genome was sequenced, they shared it freely with everyone in the world," he noted.

"So to put it in a competitive sense is probably not accurate. I would say that it's a collaborative race."


Related Links
Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola


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EPIDEMICS
WHO warns overseas virus spread may be 'tip of the iceberg'
Geneva (AFP) Feb 10, 2020
The head of the World Health Organization has warned that confirmed cases of coronavirus being transmitted by people who have never travelled to China could be the "tip of the iceberg". Tedros Adhanom Ghebreyesus' remarks come as members of a WHO-led "international expert mission" flew to China on Monday to help coordinate a response to the outbreak that has so far infected more than 40,000 people and killed 908 in the country. "There've been some concerning instances of onward #2019nCoV spread ... read more

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